Avery MacLeod McCarty Experiment: Molecular Basis of Inheritance ||Class 12 Biology


Oswald Avery, Colin MacLeod and Maclyn McCarty (1933-44) worked to determine the biochemical nature of transforming principle in Griffith experiment. They purified biochemicals (proteins, RNA, DNA) from heat killed S-cells and discovered that DNA alone from S-bacteria caused R-bacteria to be transformed.
     They also discovered that protease (protein digesting enzyme) and RNAses (RNA-digesting enzymes) did not affect transformation. Digestion with DNAse inhibit transformation, indicating that DNA caused transformation. They concluded that DNA is the hereditary material.


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